Human gamma delta T cells recognize tumor-derived AGR2Chinese Full Text
DONG Qingqing;CHEN Hui;ZHANG Jianmin;HE Wei;State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy Medical Science ＆ School of Basic Medicine, Peking Union Medical College;
Abstract: To identify tumor-associated protein ligands recognized by human γδT cell, human proteome microarray was screened with peptides from CDR3δ. Our data showed that six candidate protein ligands binding to biotin-labeled CDR3δ peptides were selected, including PHF21 A, LDB3, SYF2, PPP1 R14 A, AGR2 and SYAP1. Flow cytometry showed that AGR2 was expressed in several cancer cell lines. Pre-incubating with GST-AGR2 could significantly enhance the cytotoxicity efficiency of γδT cells against breast cance... More
- DOI：
10.13431/j.cnki.immunol.j.20180102
- Series：
(E) Medicine ＆ Public Health
- Subject：
Oncology
- Classification Code：
R730.3
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