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China Pharmacy. 2016, (04) Core

Identification and Analysis of Apigenin Metabolites in RatsChinese Full TextEnglish Full Text (MT)

ZHANG Yazhou;WANG Tao;ZOU Shuliang;LIU Hailin;YAN Chen;School of Pharmaceutical Engineering,Guizhou Institute of Technology;Guangxi Medicinal Botanical Garden;Anshun Municipal Hospital;

Abstract: OBJECTIVE:To clarify the bio-transformation form of apigenin in rats,and to speculate its possible metabolic pathway. METHODS:Rats were divided into blank group and medication group（apigenin 200 mg/kg,i.g.）with 6 rats in each group.Urine and feces samples were collected from 2 groups within 24 h after medication. After corresponding treatment,urine and feces samples were analyzed and detected by HPLC-IT-TOF-MSnunder cation mode and anion mode. RESULTS:9 metabolites were identified in urine sampl... More
Keywords：

Apigenin; HPLC-IT-TOF-MSn; Rats; Urine; Feces; Metabolites; Identification; Analysis;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Traditional Chinese Medicinal Herbs

  • Classification Code：

    R285.5

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