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Immunological Journal. 2015, (10) Core

Progress in signaling pathways of macrophage M1/2 polarizationChinese Full Text

RUAN Jingyao;CHEN Bicheng;ZHANG Xile;ZHANG Rong;HUANG Huanjie;First Clinical Medical School, Wenzhou Medical University;Department of Surgery,First Affiliated Hospital of Wenzhou Medical University;

Abstract: Plasticity and inflammatory factor-induced heterogeneity are main characteristics of macrophages.Thus, different environment-derived stimuli could induce the macrophage phenotypic polarization, such as classically activated macrophage（M1） and alternatively activated macrophage（M2）. And the functions of the two kinds of polarization states are almost antistatic on each other. Macrophage polarization is a complex process, in which more than one factor interact on each other and regulated by a vari... More
Keywords：

Macrophage polarization; Classic activation; Substitutive activation; Signaling pathway;

  • DOI：

    10.13431/j.cnki.immunol.j.20150192

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Fundamental Medicine

  • Classification Code：

    R392.12

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