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Acta Physiologica Sinica. 2018, (01) Core

Acetylcholine suppresses microglial inflammatory response in rats via acting on microglial α7nAChRChinese Full Text

JIANG Yong-Ying;LI Lin;SHEN Wei-Xing;QIU Yi-Hua;PENG Yu-Ping;Department of Physiology, Medical School, Nantong University;

Abstract: Microglia are the main immune cells in the central nervous system. In the present study, the mechanism for acetylcholine（ACh） inhibiting microglial inflammatory response was investigated. Primary culture of microglia was isolated from cerebral cortex of Sprague-Dawley（SD） rats. Lipopolysaccharide（LPS） was used to activate the microglia to induce inflammatory response, and then the microglia were treated with ACh for 24 h. Protein expressions of several inflammatory factors, insulin-like growth f... More
Keywords：

acetylcholine; α7 nicotinic acetylcholine receptors; microglia; lipopolysaccharide;

  • DOI：

    10.13294/j.aps.2018.0011

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Neurology

  • Classification Code：

    R741

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