Knowledge Network Node
Acta Physiologica Sinica. 2018, (06) Core

Role of cytochrome P450 epoxygenase-dependent arachidonic acid metabolites in kidney physiology and diseasesEnglish Full TextEnglish Full Text (MT)

FANG Qin;CHEN Guang-Zhi;WANG Yan;WANG Dao-Wen;Division of Cardiology, Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders (Huazhong University of Science and Technology);

Abstract: Kidney diseases are important causes of mortality world widely. Renal microvascular dysfunction plays a pivotal role in the development of kidney diseases. Pharmacological and biochemical tools have been used to conduct detailed studies on the metabolization of arachidonic acid by cytochrome P450（CYP450） in renal microvasculature. CYP450 epoxygenase metabolites epoxyeicosatrienoic acids（EETs） are mainly produced in renal microvessels. EETs exhibit renoprotective effects through vasodilation, ant... More
Keywords：

cytochrome P450（CYP450） epoxygenase; epoxyeicosatrienoic acid（EET）; kidney disease;

  • DOI：

    10.13294/j.aps.2018.0074

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Urology

  • Classification Code：

    R692

Download the mobile appuse the app to scan this coderead the article.

Tips: Please download CAJViewer to view CAJ format full text.

Download: 456 Page: 591-599 Pagecount: 9 Size: 595K

Related Literature
  • Similar Article
  • Reader Recommendation
  • Associated Author