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Acta Physiologica Sinica. 2019, (02) Core

Role of pregnane X receptor（PXR） in endobiotic metabolismChinese Full TextEnglish Full Text (MT)

LUAN Zhi-Lin;HUO Xiao-Xiao;GUAN You-Fei;ZHANG Xiao-Yan;Advanced Institute for Medical Sciences, Dalian Medical University;

Abstract: As a member of the nuclear receptor superfamily, the pregnane X receptor（PXR） is a ligand-activated transcription factor. PXR is highly expressed in liver and intestinal tissues, and also found in other tissues and organs, such as stomach and kidney. After heterodimerization with retinoid X receptor（RXR）, PXR recruits numerous co-activating factors, and binds to specific DNA response elements to perform transcriptional regulation of the downstream target genes. As an acknowledged receptor for xe... More
Keywords：

pregnane X receptor; transcriptional regulation; endobiotics; metabolism;

  • DOI：

    10.13294/j.aps.2018.0080

  • Series：

    (E) Medicine ＆ Public Health; (A) Mathematics/ Physics/ Mechanics/ Astronomy

  • Subject：

    Biology; Fundamental Medicine

  • Classification Code：

    R33

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