Electrophysiological phenotypes of synaptic transmission and neural network in hippocampal neurons of the α7-nAChR knockout miceEnglish Full TextEnglish Full Text (MT)
ZHENG Chao;GAO Ling-Yun;ZHANG Huan-Huan;ZHA Ying-Ying;WANG Meng-Ya;Cell Electrophysiology Laboratory, Wannan Medical College;
Abstract: It was reported that α7 nicotinic acetylcholine receptor（α7-nAChR） knockout（α7 KO） mice showed few functional phenotypes. The purpose of this study was to investigate the effect of α7 KO on the electrophysiological characteristics of hippocampus in mice. The effect of α7 KO on hippocampal CA3-CA1 synaptic transmission in mice was evaluated by standard extracellular field potential recordings. The electrophysiological phenotype of γ-aminobutyrate A receptors（GABAA-Rs） of single hippoca... More
Keywords：
hippocampus; nicotinic acetylcholine receptor（nAChR）; gene knockout; development; synaptic transmission; neural oscillations;
- DOI：
10.13294/j.aps.2018.0089
- Series：
(E) Medicine ＆ Public Health
- Subject：
Fundamental Medicine
- Classification Code：
R338
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