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Acta Physiologica Sinica. 2019, (02) Core

miR-494-3p reduces insulin sensitivity in diabetic cardiomyocytes by down-regulation of insulin receptor substrate 1Chinese Full TextEnglish Full Text (MT)

WU Jie;QIN Xing-Hua;HOU Zuo-Xu;FU Zi-Hao;LI Guo-Hua;YANG Hong-Yan;ZHANG Xing;GAO Feng;School of Aerospace Medicine, the Fourth Military Medical University;

Abstract: More and more evidence suggests that microRNA is widely involved in the regulation of cardiovascular function. Our preliminary experiment showed that miR-494-3p was increased in heart of diabetic rats, and miR-494-3p was reported to be related to metabolism such as obesity and exercise. Therefore, this study was aimed to explore the role of miR-494-3p in diabetic myocardial insulin sensitivity and the related mechanism. The diabetic rat model was induced by high fat diet（45 kcal% fat, 12 weeks） ... More
Keywords：

miR-494-3p; type 2 diabetes; cardiomyocyte; insulin receptor substrate 1; insulin resistance;

  • DOI：

    10.13294/j.aps.2018.0095

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Endocrine and Systemic Disease

  • Classification Code：

    R587.2

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