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Acta Physiologica Sinica. 2019, (05) Core

Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine toleranceChinese Full TextEnglish Full Text (MT)

LI You-Ping;JIANG Jian-Ping;College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neuro Biology;

Abstract: Rodent MrgC receptor（Mas-related G-protein-coupled receptor subtype C） shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1（hMrgX1）. Therefore, researchers generally explore the role of hMrgX1 by studying the function of MrgC receptor. Murine MrgC receptor is uniquely expressed in small-diameter neurons of dorsal root ganglia（DRG） and trigeminal ganglia（TG）, which is closely related to the transmission process o... More
Keywords：

human Mas-related gene X receptor 1; Mas-related G-protein-coupled receptor subtype C; dorsal root ganglion; spinal dorsal horn; pathological pain; morphine tolerance;

  • DOI：

    10.13294/j.aps.2019.0031

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Clinical Medicine

  • Classification Code：

    R402

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