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Chemistry ＆ Bioengineering. 2012, (10)

Optimization of Daptomycin Fermentation Medium by Response Surface MethodologyChinese Full Text

YU Guang-hai,YIN Yan-li,ZHANG Yao(Department of Bio-Engineering,College of Biological Engineering, Henan University of Technology,Zhengzhou 450001,China)

Abstract: Daptomycin fermentation medium was optimized by Plackett-Burman design,the steepest ascent design and response surface methodology in this paper.Experimental data were analyzed by software Design expert 7.0.The results showed that the main influential factors for daptomycin production were dextrin,soluble starch,L-aspartic acid,and their optimum concentration was 7.0 g·L-1,6.66 g·L-1,0.4 g·L-1,respectively.Under the optimized conditions,the production of daptomycin could reach 185.3 mg·L-1,which... More
Keywords：

Plackett-Burman design; the steepest ascent design; response surface methodology; daptomycin; fermentation medium;

  • Series：

    (B) Chemistry/ Metallurgy/ Environment/ Mine Industry

  • Subject：

    Organic Chemical Industry

  • Classification Code：

    TQ465.1

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