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Journal of Chinese Practical Diagnosis and Therapy. 2018, (03)

Influence of PI3K/Akt signaling pathway on the proliferation of HT-29 cellsChinese Full Text

TANG Jian;HE Ju-qiao;YANG Yi-ling;WANG Zhen-ran;Department of Traditional Chinese Medicine Surgery,the First Hospital of Hunan University of Traditional Chinese Medicine;

Abstract: Objective To investigate the influence of PI3K/Akt signaling pathway on the proliferation of HT-29 human colon cancer cells.Methods The HT-29 cells were divided into cancer group and inhibitor group,and the adjacent normal cells were as controls（control group）.The cells in logarithmic growth phase were tested.Inhibitor group was interfered by 10μL of PI3K/Akt signaling inhibitor LY294002 + culture medium.Cancer group and control group were interfered by 10μL of normal saline + culture medium.MTT... More
Keywords：

Human colon cancer; HT-29 cells; PI3K/Akt signaling pathway; cell apoptosis; cell cycle;

  • DOI：

    10.13507/j.issn.1674-3474.2018.03.004

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Oncology

  • Classification Code：

    R735.35

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