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Pharmaceutical applications of chiral gas chromatography

Xiang,Y.~* Sluggett,G.W. Analytical Research and Development,Pfizer Global Research and Development,Eastern Point Road,Groton,CT 06340,USA

Abstract: For any chiral drug candidate,its enantiomer can produce different pharmacological,toxicological,metabolic, and pharmacokinetic properties.United States FDA Guidance infers that control of enantiomeric impurities is critical in pharmaceutical manufacturing.High performance liquid chromatography（HPLC）methods are most widely used for chiral analysis of pharmaceuticals.However,most chiral HPLC methods suffer from lower efficiency,leading to relatively broad peaks.If the pharmaceuticals lack a stron... More
Keywords：

Pharmaceutical; Chiral capillary gas chromatography; Derivatization;

Conference Name：

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

Conference Time：

2007-06

Conference Place：

中国辽宁大连

  • Series：

    (B) Chemistry/ Metallurgy/ Environment/ Mine Industry

  • Subject：

    Chemistry

  • Classification Code：

    O657.71

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