Lung microbiome mediates the progression from chronic obstructive pulmonary disease to lung cancer through inflammationChinese Full TextEnglish Full Text (MT)
Yajie Wang;Shuangshuang Wu;Jiang Chu;Xiangyang Kong;Genetics and Pharmacogenomics Laboratory, Medical School, Kunming University of Science and Technology;
Abstract: Lung microbiome exists in the respiratory tract and parenchymal tissues. It mediates lung injury through a variety of mechanisms, including bacterial disturbance, metabolites, inflammatory response, immune response, and genotoxicity. Accumulating evidences suggest that changes in lung microbiome correlates with chronic obstructive pulmonary disease（COPD） and lung cancer, and the microbiome promotes the progression from COPD to lung cancer. In this review, we mainly introduce the impairment of the homeostasis of the lung microbiome and its inflammation that leads to COPD and lung cancer, then focus on how the microbiome mediates the progression from COPD to lung cancer through inflammatory response. The review may provide a new theoretical basis for clinical prevention, optimal treatment strategy and design of new drugs for COPD and lung cancer.
Keywords：
lung microbiome; chronic obstructive pulmonary disease; lung cancer; diversity; inflammation;
- DOI：
10.16288/j.yczz.20-315
- Series：
(A) Mathematics/ Physics/ Mechanics/ Astronomy; (E) Medicine ＆ Public Health
- Subject：
Oncology
- Classification Code：
R734.2
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- BETABETAEnglish HTML (MT)
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 669 Page: 30-39 Pagecount: 10 Size: 249K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author