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Acta Pharmaceutica Sinica. 2021, (07) Core

Research advances on stimulator of interferon genes（STING） and its agonistsChinese Full Text

CHANG Jia-jia;HOU Shi;YAN Xin-lin;XIAO Jun-hai;School of Chemical Engineering and Technology, Tianjin University;Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences;

Abstract: As a key signal transduction molecule involved in the innate immune response, stimulator of interferon genes（STING） is triggered by cytosolic DNA from pathogen and host origins, and plays an important role in inducing the secretion of type I interferons and proinflammatory cytokines, thereby defending against viral and intracellular bacterial infections and regulating the production of spontaneous antitumor immune responses in vivo.Thus, STING agonists have shown useful therapeutic effects for p... More
Keywords：

stimulator of interferon genes; cGAS-STING pathway; STING agonist; crystal structure; structureactivity relationship;

  • DOI：

    10.16438/j.0513-4870.2021-0223

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Fundamental Medicine

  • Classification Code：

    R392

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