Pharmacological activities of berberine and strategies to improve its oral bioavailabilityChinese Full Text
ZHOU Jian-xiong;WU Song-gu;GONG Jun-bo;WEI Zhen-ping;School of Chemical Engineering,Tianjin University;
Abstract: Berberine is a naturally occurring benzylisoquinoline alkaloid with a wide range of pharmacological activities, such as antibacterial, anticancer, hypolipidemic, antidiabetic and antidiarrheal. Although berberine has a wide range of curative effects, the extremely low bioavailability（＜ 1%） limits its clinical application. Pure berberine preparations have not yet been approved for any specific disease. The low oral bioavailability of berberine is mainly due to poor solubility caused by self-aggre... More
Keywords：
berberine; pharmacological activity; drug metabolism; pharmacokinetics; oral bioavailability;
- DOI：
10.16438/j.0513-4870.2021-1302
- Series：
(E) Medicine ＆ Public Health
- Subject：
Traditional Chinese Medicinal Herbs
- Classification Code：
R285
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