Acta Pharmaceutica Sinica. 2022, (07) Core

Research progress of cystic fibrosis and its therapiesChinese Full Text

LIN Lin;WANG Yan;WU Chuan-bin;ZHU Chun-e;School of Chinese Materia Medica, Guangdong Pharmaceutical University;School of Pharmaceutical Sciences, Jinan University;

Abstract: Cystic fibrosis（CF） is a common and life-threatening autosomal recessive disorder in Caucasians populations. The disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator（CFTR） gene. The absence of mature CFTR at the correct cellular location or dysfunction of CFTR proteins has been observed in CF patients. CF is frequently accompanied by a variety of complex complications, such as impairments in pulmonary functions, which may lead to successive infections and res... More

Keywords：

cystic fibrosis; cystic fibrosis transmembrane conductance regulator; gene mutation; CFTR modulator; mechanism of action of drugs; antibiotic;

DOI：
10.16438/j.0513-4870.2021-1750
Series：
(E) Medicine ＆ Public Health
Subject：
Endocrine and Systemic Disease
Classification Code：
R596.1

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