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An analysis of the influence of protein intrinsic structural flexibility on its thermal unfolding behavior

Xian-jin Xu~1,Ji-guoSu~(1,2),Wei-zu Chen~1, Cun-xin Wang 1 College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124, China 2College of Science,Yanshan University,Qinhuangdao 066004,China

Abstract: <正>The influence of the protein topology-encoded flexibility on its thermal unfolding motions was studied in the present work.The intrinsic flexibility of protein topology was obtained by the anisotropic network model(ANM).The ANM has been largely used to investigate protein collective functional motions,but it is not well elucidated if this model can also reveal the preferred large-scale motions during protein unfolding.A small protein barnase is used as a typical case study to explore the rela... More
Conference Name:

第四届全国生物信息学与系统生物学学术大会

Conference Time:

2010-10-06

Conference Place:

中国浙江杭州

  • Series:

    (A) Mathematics/ Physics/ Mechanics/ Astronomy

  • Subject:

    Biology

  • Classification Code:

    Q51

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