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Acta Physiologica Sinica. 2007, (02) Core

Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertensionChinese Full Text

GONG Yong-Sheng, FAN Xiao-Fang, WU Xiao-Mai, HU Liang-Gang, TANG Chao-Shu, PANG Yong-Zheng, QI Yong-Fen Institute of Cor Pulmonale and Teaching Centre of Functional Experiment, Wenzhou Medical College, Wenzhou 325035, China; Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China

Abstract: The purpose of the present study was to explore the expression changes of intermedin/adrenomedullin 2 （IMD/ADM2）, a novel small molecular bioactive peptide, and its receptors, calcitonin receptor-like receptor （CRLR） and receptor activity modifying proteins （RAMP1,RAMP2, RAMP3） in the right ventricle of rats with chronic hypoxia-induced pulmonary hypertension. Twenty male Sprague-Dawley rats were randomly divided into 4-week hypoxia group and normal control group （each n=10）. The rats in hypoxia... More
Keywords：

adrenomedullin; intermedin; receptor; hypoxia; hypertension, pulmonary;

  • DOI：

    10.13294/j.aps.2007.02.015

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Fundamental Medicine

  • Classification Code：

    R363

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