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Chinese Journal of Pharmacology and Toxicology. Core
(Accepted Version) Online First Publishing Date: 2021-02-24 11:35:57

Comprehensive serum metabolomic study of hepatocellular carcinoma by UPLC-QTOF-MS/MS based non-targeted strategyrevokeChinese Full Text

WANG Shu-feng;BAI Zhao-fang;YANG Xin;WANG Xin-zheng;HE Kun;WANG Hong-xia;

Abstract: OBJECTIVE Comparative serum metabolomic study of hepatocellular carcinoma（HCC） and liver cirrhosis（LC） was performed to investigate the metabolome alteration of HCC for providing potential diagnostic biomarker and therapeutic targets for clinical treatments. METHODS The serum metabolites of 50 HCC and 50 LC patients were identified and quantified by ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry（UPLC-QTOF-MS/MS） techniques.The complementary separation of reve... More
Keywords：

hepatocellular carcinoma; serum; UPLC-QTOF-MS/MS; non-targeted metabolomic;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Digestive System Disease; Oncology

  • Classification Code：

    R735.7;R575.2

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