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Journal of Air Force Medical University.
(Accepted Version) Online First Publishing Date: 2025-02-28 09:00:05

Metabolites mediate immune cells to participate in the occurrence of non-alcoholic fatty liver disease: a multivariate Mendelian randomization analysisChinese Full Text

DAI Hongyuan;QIAN Zhenwei;LU Yinying;HAN Juqiang;

Abstract: Objective To investigate the independent causal relationship between immune cells and metabolites in the pathogenesis of non-alcoholic fatty liver disease （NAFLD）， and to pay attention to the mediating role of metabolites in NAFLD caused by immune cell changes， so as to lay the foundation for further research on the pathogenesis of NAFLD. Methods The immune cells and metabolites associated with NAFLD were screened by Mendelian randomization （MR） analysis. Then， MR was performed separately to obt... More
Keywords：

non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; Mendelian randomization; metabolites; CD4+ T cells; Naive CD4+ T cells;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Digestive System Disease

  • Classification Code：

    R575.5

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