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Journal of Biology. 2020, (05) Core

Knockdown ofSLC2A6gene inhibits the proliferation of lung adenocarcinoma A549 cells by inducing G2/M arrestEnglish Full TextEnglish Full Text (MT)

TIAN Di;CHEN Chun-fa;LIU Jia;HUANG Zhao;ZHAO Ping;Institute for Medical Biology ＆ Hubei Provincial Key Laboratory for Protection and Application of Special Plants in the Wuling Area of China,College of Life Sciences,South-Central University for Nationalities,Hubei Medical Biology International Science and Technology Cooperation Base;

Abstract: SLC2A6 is a member of the facilitative glucose transporter family,it codes GLUT6 protein.SLC2A6 is up-regulated in several numerous cancers,but is not widely expressed in normal tissues.In order to elucidate the functions and underlying mechanisms for SLC2A6 controlling cancer cell proliferation and apoptosis,we screened two SLC2A6 knockdown lung adenocarcinoma A549 cell lines by CRISPR/Cas9 to illustrate the effects of SLC2A6 on biological process.SLC2A6 expression in mRNA and protein levels ha... More
Keywords：

SLC2A6; A549 cells; CRISPR/Cas9; cell proliferation; cell cycle;

  • Series：

    (A) Mathematics/ Physics/ Mechanics/ Astronomy; (E) Medicine ＆ Public Health

  • Subject：

    Oncology

  • Classification Code：

    R734.2

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