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Journal of North Sichuan Medical College. 2022, (12)

Homharringtonine reverses cisplatin resistance in ovarian cancer cells by inhibiting ERK1/2 signaling pathwayChinese Full Text

CHENG Chen;YANG Jian;QIN Gong-zhao;JU Sheng;Department of Gynecology,Suzhou Hospital Affiliated to Nanjing Medical University;Department of Thoracic Surgery,the First Affiliated Hospital of Suzhou University;

Abstract: Objective:To study the mechanism of cisplatin（DDP） resistance in homoharringtonine（HHT） ovarian cancer cells.Methods:DDP-resistant ovarian cancer cells A2780/DPP were divided into control group, DDP group, HHT group, combined group（DDP+ HTT）,ERK1/2 inhibitor group（PD98059）,DDP+ERK1/2 inhibitor group（DDP+PD98059）,ERK1/2 activator group（ISO）,and combined+ERK1/2 activator group（DDP+HTT+ISO）.Proliferation was detected by CCK-8 assay, apoptosis was detected by flow cytometry, and protein expressions ... More
Keywords：

Homharringtonine（HHT）; Ovarian cancer; Cisplatin（DDP） resistance; ERK1/2 signaling;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Traditional Chinese Medicinal Herbs

  • Classification Code：

    R285

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