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Journal of China University of Metrology. 2022, (02)

Advances in the activation of cryptic biosynthetic gene clusters of Streptomyces in biosynthesis of natural productsChinese Full Text

MA Zheng;SHI Yue;ZHANG Jinyao;YU Xiaoping;Zhejiang Provincial Key Laboratory of Biometrology,Inspection and Quarantine,Collegeof Life Sciences,China Jiliang University;

Abstract: Aims: In this study, advances in activation of silent secondary metabolite biosynthetic gene clusters in Streptomyces were summarized and the applications were briefly discussed and proposed in future.Methods: The development of genome-sequencing reveals that the dozens of secondary metabolite biosynthetic gene cluster are located at genome of Streptomyces. However, these secondary metabolite biosynthetic gene clusters were “silent”, namely were not expressed or slightly expressed under normal c... More
Keywords：

Streptomyces; CBGCs; heterologous expression; ribosome engineering; reporter gene; activation;

  • Series：

    (C) Architecture/ Energy/ Traffic/ Electromechanics, etc; (A) Mathematics/ Physics/ Mechanics/ Astronomy

  • Subject：

    Biology

  • Classification Code：

    Q789

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