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Journal of Clinical and Pathological Research. 2023, (02)

Protective effect of loganin on intestinal mucosal injury and TLR4/NF-κB pathway in severely burned ratsChinese Full Text

WEN Hailing;YANG Jingzhe;MENG Xiangxi;ZHANG Xiangyun;Department of Burn and Plastic Surgery, South District Hospital, Affiliated Hospital of Chengde Medical University;Department of Outpatient , Chengde Retired Cadres Rest Center of Hebei Military Region;

Abstract: Objective: To investigate the protective effect of loganin on intestinal mucosal injury in severely burned rats and the effect of Toll-like receptor 4（TLR4）/nuclear transcription factor-κB（NF-κB） inflammatory pathway.Methods: Thirty male SD rats were randomly divided into a control group, a burn group, and a loganin group, each group with 10 rats. The burn group and loganin group were subjected to 30% total body surface area（TBSA） III degree burn on the back, and the control group was subjected ... More
Keywords：

loganin; burn; intestinal mucosa; inflammatory reaction; Toll-like receptor 4/nuclear transcription factor-κB signaling pathway;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Traditional Chinese Medicinal Herbs

  • Classification Code：

    R285.5

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