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Chinese Hepatology. 2024, (11)

Association of blood metabolites with primary sclerosing cholangitis risk: a two-sample Mendelian randomized studyChinese Full Text

WANG Zeng-xiu;WU Wei-feng;Department of Hepatology, the Second Hospital of Nanjing,Nanjing University of Chinese Medicine;

Abstract: Objective To investigate the association between blood metabolite levels and the risk of primary sclerosing cholangitis（PSC） using Mendelian randomization. Methods Genome-wide association study（GWAS） data for PSC and blood metabolites were obtained. Single nucleotide polymorphisms（SNPs） were selected as instrumental variables, and two-sample Mendelian randomization（MR） analyses were conducted using inverse variance weighting, the weighted median method, and MR-Egger regression. Results Higher le... More
Keywords：

Blood metabolites; Mendelian randomization; Correlation study; Primary sclerosing cholangitis;

  • DOI：

    10.14000/j.cnki.issn.1008-1704.2024.11.034

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Digestive System Disease

  • Classification Code：

    R575.7

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