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Chinese Journal of Pathophysiology. 2025, (02) Core

Recent advances in ductular reaction in the context of primary sclerosing cholangitis: mechanistic insights and targeted therapyChinese Full Text

CUI Yiming;HU Bo;LIN Haoting;WANG Jiamin;HONG Jian;TAO Ping;Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University;Biotechnological Institute of Chinese Materia Medica, Jinan University;The First Affiliated Hospital of Jinan University;

Abstract: Primary sclerosing cholangitis（PSC） is an autoimmune disease characterized by chronic inflammation and progressive fibrosis that affects both intrahepatic and extrahepatic bile ducts. Despite ongoing research, the underlying mechanisms of PSC pathogenesis remain incompletely understood. The ductular reaction is not only a key pathological feature of PSC but also serves as a driving force in its progression. This review examines the promoting effects of the ductular reaction on PSC advancement fr... More
Keywords：

primary sclerosing cholangitis; ductular reaction; inflammation; fibrosis;

  • Series：

    (E) Medicine ＆ Public Health

  • Subject：

    Digestive System Disease

  • Classification Code：

    R575.7

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